Clotting activity of polyphosphate-functionalized silica nanoparticles.

نویسندگان

  • Damien Kudela
  • Stephanie A Smith
  • Anna May-Masnou
  • Gary B Braun
  • Alessia Pallaoro
  • Chi K Nguyen
  • Tracy T Chuong
  • Sara Nownes
  • Riley Allen
  • Nicholas R Parker
  • Hooman H Rashidi
  • James H Morrissey
  • Galen D Stucky
چکیده

We present a silica nanoparticle (SNP) functionalized with polyphosphate (polyP) that accelerates the natural clotting process of the body. SNPs initiate the contact pathway of the blood-clotting system; short-chain polyP accelerates the common pathway by the rapid formation of thrombin, which enhances the overall blood-clotting system, both by accelerating fibrin generation and by facilitating the regulatory anticoagulation mechanisms essential for hemostasis. Analysis of the clotting properties of bare SNPs, bare polyP, and polyP-functionalized SNPs in plasma demonstrated that the attachment of polyP to SNPs to form polyP-SNPs creates a substantially enhanced synergistic effect that lowers clotting time and increases thrombin production at low concentrations. PolyP-SNP even retains its clotting function at ambient temperature. The polyP-SNP system has the potential to significantly improve trauma-treatment protocols and outcomes in hospital and prehospital settings.

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عنوان ژورنال:
  • Angewandte Chemie

دوره 54 13  شماره 

صفحات  -

تاریخ انتشار 2015